Cholesterol, Non–High-Density Lipoprotein (non-HDL-C)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Cholesterol, Non–High-density Lipoprotein (non-HDL-C). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed May 26, 2024.
Last Updated: May 9, 2022
Last Reviewed: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Cholesterol, non–high-density lipoprotein (non-HDL-C) [S/P]

Reference range, target level, or decision threshold

Depends on cardiovascular risk:CPG

Extremely high: <1.8 mmol/L (70 mg/dL)

Very high: <2.2 mmol/L (85 mg/dL)

High: <2.6 mmol/L (100 mg/dL)

Moderate: <3.4 mmol/L (130 mg/dL)

[mmol/L] × 38.5 = [mg/dL]

Interpretation of results

↑ Familial hypercholesterolemia, familial apolipoprotein B100 deficiency, polygenic hypercholesterolemia, hypothyroidism, nephrotic syndrome, CKD, liver diseases with cholestasis, drugs (progestogens, glucocorticoids, protease inhibitors used in HIV infection)

↓ Hyperthyroidism, advanced cirrhosis and other severe liver injuries, sepsis, cachexia

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