Thrombocytopenia Caused by Decreased Platelet Production

How to Cite This Chapter: Arnold DM, Crowther M, Zawilska K, Młynarski W. Thrombocytopenia Caused by Decreased Platelet Production. McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed May 22, 2024.
Last Updated: September 19, 2020
Last Reviewed: September 19, 2020
Chapter Information


Thrombocytopenia found in the complete blood count in a patient with a certain clinical condition (causes: see Platelet Disorders: General Considerations). Bone marrow aspiration and biopsy reveal reduced megakaryocyte counts or their abnormal morphology. Other diagnostic studies depend on the suspected underlying condition.

Treatment Top

Repeated platelet transfusion is likely to be associated with refractoriness; thus, transfusion should be used sparingly.

1. Treatment of inherited disease: Platelet concentrate transfusions.

2. Treatment of acquired disease: Eliminate the causative factor or factors, treat the underlying condition, and administer platelet concentrate when necessary.

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