Rh0(D) Immunoglobulin (RhIG)

How to Cite This Chapter: Morin P-A, Ning S, Łętowska M, Rosiek A. Rh0(D) Immunoglobulin (RhIG). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. https://empendium.com/mcmtextbook/chapter/B31.II.15.62.4.5. Accessed November 30, 2021.
Last Updated: February 19, 2020
Last Reviewed: January 22, 2021
Chapter Information

Rh0(D) immunoglobulin (RhIG) is a blood product that contains anti-D immunoglobulins derived from human blood donors administered for the purpose of preventing RhD alloimmunization.

IndicationsTop

RhIG is most commonly administered to nonalloimmunized, RhD-negative women during pregnancy, following delivery, and at the time of any complications of pregnancy during which fetal-maternal blood exchange may occur. The dosage administered depends on a variety of factors, including timing in and after pregnancy, extent of fetal-maternal blood exchange, manufacturer recommendations, and jurisdictional guidelines.

Indications for RhIG administration outside of pregnancy include administration of RhD-positive platelets to an RhD-negative recipient, prevention of RhD alloimmunization, and treatment of immune thrombocytopenia (ITP).

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