Prothrombin complex concentrates (PCCs) are coagulation factor concentrates that contain factors II, VII, IX, and X made from virally inactivated pooled plasma donations from thousands of blood donors. Storage and infusion rates vary with manufacturer recommendations.
Available as lyophilized powders that must be reconstituted, PCCs are most commonly administered for the rapid reversal of warfarin-associated bleeding. PCCs are also used for the reversal of life-threatening bleeding due to anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban. The maximum dose should not be >3000 IU.