Prothrombin Complex Concentrates (PCCs)

How to Cite This Chapter: Morin P-A, Ning S, Łętowska M, Rosiek A. Prothrombin Complex Concentrates (PCCs). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed November 29, 2023.
Last Updated: February 19, 2020
Last Reviewed: January 22, 2021
Chapter Information

Prothrombin complex concentrates (PCCs) are coagulation factor concentrates that contain factors II, VII, IX, and X made from virally inactivated pooled plasma donations from thousands of blood donors. Storage and infusion rates vary with manufacturer recommendations.


Available as lyophilized powders that must be reconstituted, PCCs are most commonly administered for the rapid reversal of warfarin-associated bleeding. PCCs are also used for the reversal of life-threatening bleeding due to anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban. The maximum dose should not be >3000 IU.

We would love to hear from you

Comments, mistakes, suggestions?

We use cookies to ensure you get the best browsing experience on our website. Refer to our Cookies Information and Privacy Policy for more details.