What are the tolerance and adverse effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors?
Ian Graham: These are given by injection. There is very little cross-interaction with drugs that are given orally. In general, so far, the side-effect profile of PCSK9 inhibitors has been very satisfactory. Some people get some irritation at the injection site, some people get a flu-like illness, but those are the only real major side effects that have been recorded. There has been just a suggestion of whether cognitive function might be affected but this has not been confirmed. It is something that is being monitored in ongoing trials.