Screening for primary hyperaldosteronism

What are the indications for screening for primary hyperaldosteronism?

Ally Prebtani, MD: Primary aldosteronism is much more common than we think. When would you screen someone for primary aldosteronism? If someone has significant hypertension that is not explained by other causes, if someone has hypokalemia or easily provoked hypokalemia with any of the agents, if someone has low or normal potassium on drugs that should elevate potassium, if someone has a family history of hyperaldosteronism, also if someone is refractory to multiple medical therapies—for example, >3 drugs—and if someone requires control with ≥4 drugs, think about the condition of primary hyperaldosteronism.