PPIs in patients receiving NSAIDs

Paul Moayyedi

Should proton pump inhibitors (PPIs) be prescribed in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs)?

Paul Moayyedi, MB ChB, PhD: I would say they are not mandatory except in certain circumstances. A young person can just take a nonsteroidal alone for pain in their knee. Even if they need to take it more long term, a young person is not going to be at risk of gastrointestinal bleeding.

It is usually those over 65 years with other risk factors, such as taking aspirin as well, other anticoagulant, previous history of ulcer disease; these are all cases when I would give a PPI as well as a nonsteroidal. But it would not be in every person who takes nonsteroidals.

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