Dopamine in the treatment of septic shock

Emilie Belley-Côté


De Backer D, Biston P, Devriendt J, et al; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118. PubMed PMID: 20200382.

Is there a place for dopamine in the treatment of septic shock?

Emilie Belley-Côté, MD: The only time I will personally use dopamine after the results of the SOAP II (Sepsis Occurrence in Acutely Ill Patients II) trial for septic shock is when patients have relative chronotropic insufficiency, so if their heart rate is too slow in relation to their septic state. If someone has septic shock with a heart rate that is 60 or 70, for example, I will use dopamine to try to bring the heart rate and cardiac output up. Otherwise, my first line is norepinephrine.

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