Antithrombotic treatment in nephrotic syndrome

Jürgen Floege

Is nephrotic syndrome a recommendation for antithrombotic treatment? If yes, when should the treatment be started and how long should it last?

Jürgen Floege: Yes, it is, in particular if you have membranous glomerulonephritis. For some reason that is associated with a particularly high risk of thromboembolism. Usually we use albumin as a surrogate marker to estimate the risk. My rule of thumb is that if the serum albumin is below 20 g/L, I use full anticoagulation in these patients. I will show in my lecture [see Nephrotic syndrome in adults: current management] there are now risk calculators and they may help to give you a little bit more of an individualized approach to this. They are available on the internet.

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