The old Anthonisen criteria are often used to select patients in whom antibiotic treatment is necessary. Are these criteria evidence-based? What about patients without purulent sputum but with fever? Should we rather use antibiotics as a standard treatment in all exacerbations?
Should we always use a posteroanterior (PA) and lateral chest x-ray during the diagnostic workup of patients with respiratory signs and symptoms, or is the PA projection alone sufficient in some instances?
The recent European Respiratory Society (ERS) guidelines recommend oral corticosteroids in outpatients with COPD exacerbations, but it is a weak recommendation that may not be followed. Are there any evidence-based indications on who should receive oral corticosteroids?
How many patients with COPD in Canada are treated with long-term noninvasive ventilation? Is this number growing?
Can long-term use of inhaled corticosteroids – eg, in asthma – affect the larynx and cause dysphonia?
Should we expect any new drugs targeting the CFTR protein to be available soon?
Can we talk about postinfectious cough? What are the diagnostic criteria and available treatment options?
A study by Frat et al demonstrated that in some populations high-flow oxygen treatment can be much more effective than noninvasive mechanical ventilation. In which patients with acute respiratory insufficiency should we use high-flow oxygen therapy rather than noninvasive ventilation?
Are there any agents that have been proven effective in alleviating cough associated with infections?
What are the real-life benefits for patients with cystic fibrosis treated with drugs targeting the CFTR protein?
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