Dr Eslam Shosha, assistant professor in the Division of Neurology, Department of Medicine, McMaster University, clarifies how to identify area postrema syndrome (APS) manifested by intractable nausea, vomiting, and hiccups, presents diagnostic criteria and a severity scale, and outlines the management strategy. The webinar chaired by Dr Mark Crowther was recorded at the Chair's Medical Grand Rounds on January 6, 2022.