Dr Siraj Mithoowani, a clinical hematologist at St. Joseph's Healthcare Hamilton, specializing in benign hematology and venous thromboembolism, summarizes crucial issues related to anticoagulation, which should inform the internist's decisions in everyday practice. He advises how to select an appropriate anticoagulant drug based on treatment indications and patient characteristics, describes ways to minimize the risk of bleeding on anticoagulant therapy, and reflects on the indications for and risks of thrombolysis for acute pulmonary embolism. The webinar chaired by Dr Madeleine Verhovsek and Dr Rick Ikesaka was recorded at the Chair's Medical Grand Rounds on February 17, 2022.