Duration of PPI treatment in functional dyspepsia

Paul Moayyedi

What should be the duration of proton pump inhibitor (PPI) treatment in patients with functional dyspepsia?

Paul Moayyedi: I normally continue for 2 months and then stop. That is just my practice. Most of the studies are 2 to 4 weeks. If we are getting benefit, I like to carry on a little longer and then stop and see if the patient still needs it. If they do, they can start it again, but they should try stopping PPI every 6 months. Functional dyspepsia is a waxing and waning condition, so when we are at a quiet period, we do not need to be taking PPIs.

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