ALT and AST to exclude HBV and HCV infections

Philip N. Newsome

Dr Philip N. Newsome is a professor of experimental hepatology and director of the Centre for Liver and Gastrointestinal Research at the University of Birmingham and secretary general of the European Association for the Study of the Liver.

Do normal levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) exclude infection with hepatitis B and hepatitis C viruses?

Philip N. Newsome, MBChB, PhD: We know that liver blood tests can be abnormal in the setting of liver disease, but we also know that you can have normal liver blood tests and yet still have infection and significant fibrosis. The key thing is looking at the clinical situation rather than the blood tests in isolation.

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