Canadian flag English
McMaster Textbook of Internal Medicine

The role of seizure semiology and etiology for treatment decision-making

2023-05-17
Wieslaw Oczkowski
Recorded at the 7th McMaster International Review Course in Internal Medicine (MIRCIM).

Wieslaw Oczkowski, MD, is a professor emeritus in the Department of Medicine at McMaster University and director of the Regional Stroke Network for the Central South Ontario Region.

When using antiseizure treatment, why do we continue to rely on seizure morphology rather than use biologic, metabolic, or genetic markers in an attempt to individualize therapy (possibly with the exception of vigabatrin in infantile spasms associated with tuberous sclerosis)?

There are some epilepsy syndromes that respond to specific treatments and are genetic.

In my world, in the adult world, most epilepsy is not syndromic and genetic, it’s going to be a lot of it. I believe in the future, as the population ages and we survive other problems, we’ll have focal-onset epilepsy as the predominant type of epilepsy. The treatments for those are going to have to be very specific and including other things beyond medications.

At the moment, our best line of treatment is the appropriate anticonvulsant. We use the semiology, or the way the seizure presents, as an important way to start the treatment. The reason we do that is, for example, in focal-onset epilepsy, treatment trials have shown that one medication is better than another, while in other trials in people with generalized epilepsy it has been shown that one other medication is better than another. So again, we go back to [the statement that] it’ll be important for us to do further randomized trials on different types of epilepsy and the entire semiology and etiology of the epilepsy will still be an important component before treatment.

See also
  • Chronic seizure management in patients with drug-resistant epilepsy We have a broad and still growing selection of antiseizure medications available, and yet drug resistance remains a challenge in roughly a third of patients with epilepsy. Why is this rate so high and how can we improve chronic seizure management in these patients?
  • Recent advances in neurology If you were to name the 3 most important recent advances in neurology that are relevant for everyday practice, what would they be?
  • Novel antiseizure drugs as first-line treatment Novel antiseizure drugs are typically approved as adjunctive therapy, to be used as an add-on. It might take years until their registration is expanded to include initial monotherapy. Do you think that cenobamate and other novel drugs could reduce the rates of drug resistance when introduced earlier, even as first-line medications in selected patients?
  • The future of drug-resistant epilepsy management: new drugs, surgery, DBS What is more likely to bring a breakthrough in the management of drug-resistant epilepsy: the development of new drugs with novel mechanisms of action or wider use of nonpharmacologic interventions, such as epilepsy surgery or, possibly, DBS?

We would love to hear from you

Comments, mistakes, suggestions?

Send feedback