Biologic treatment in nonallergic asthma

What biologic treatment – if any – is currently available for nonallergic asthma patients?

Paul O’Byrne: Nonallergic asthma is often eosinophilic. In fact, in the initial studies done with the anti-interleukin (IL)-5 biologics, many of these patients were not allergic, at least as measured by either positive skin tests or elevated levels of IgE. Having nonallergic asthma certainly does not eliminate the potential benefit of anti-IL-5 monoclonals – particularly, of course, if they have a persistent airway eosinophilia.