Contraindications to the use of biologics in asthma

Are there any common contraindications to the use of biologics in asthma?

Paul O’Byrne: There have been, as yet, very few serious side effects with the biologics. There have been a few cases reported of an anaphylactic reaction with omalizumab, the anti-IgE monoclonal. It is a very rare event. So far, to my knowledge, there have not been any such reactions described with any of the anti-interleukin-5 monoclonals that I am aware of.

The main contraindication to the use of these drugs is their cost. They are very expensive and out of reach of most patients without the assistance of either the government funding or some insurance funding to help pay for them.