This review provides an updated overview of the mechanisms of action, therapeutic indications, efficacy, and safety of the currently available biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), based on the results of randomized clinical trials and real-world studies.
Chronic cough is a common condition that affects 7% to 11% of adults worldwide and accounts for a major burden of primary care visits in both developed and developing countries. The purpose of this review was to highlight the key messages on the management of chronic cough from the task force commissioned by the European Respiratory Society.
The pandemic brought with it an entire new realm of human suffering that is only indirectly related to disease itself—it relates to the societies’ ways of dealing with the illness. We propose that when making decisions about health-care interventions during this and during future pandemics, those “human-important outcomes” are carefully considered.
This review provides an overview of the available evidence on aspirin for primary cardiovascular prevention, focusing on the results of meta-analyses and strengths and pitfalls of meta-analytic assessments.
In the modern American hospital, clinicians spend as little as 12% of their time in direct contact with patients and their families. This has led to a decline in clinical examination skills and contributes to diagnostic error. In 2017, the Society of Bedside Medicine was formed to encourage innovation, education, and research on the role of the clinical encounter in 21st century medicine.
International travel has become an increasingly complex issue as a risk factor for infectious diseases. This review examines important considerations when evaluating travelers, with a special focus on the risk of emerging infectious diseases, by placing clinical syndromes in a travel context.
This review discusses the clinical presentation, diagnosis, and management of patients presenting with myxedema coma or thyroid storm. If not promptly and appropriately diagnosed and treated, both conditions are associated with poor outcomes and high mortality rates.
This review discusses herpes virus infection in patients with ulcerative colitis (UC), focusing on the prevalence and diagnosis of cytomegalovirus (CMV) infection and prevalence of single or mixed herpes virus infection in addition to CMV. The significance of CMV genotyping in UC is also examined.
This review discusses new guidelines addressing the management of patients with gastroesophageal reflux disease (GERD) and Barrett esophagus.
This review describes the role of fecal markers in the diagnostic workup of common conditions encountered in gastroenterology clinics.
McMaster Textbook of Internal Medicine acknowledges the important contribution of Cochrane Canada and its authors in development of the textbook.
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