Discontinuing other antidiabetic agents when starting insulin in type 2 diabetes

René Rodríguez-Gutiérrez

Should other antidiabetic agents be discontinued when starting insulin therapy in a patient with type 2 diabetes?

René Rodríguez-Gutiérrez, MD: Yes, particularly secretagogues, so sulfonylureas and gliptins. It is not a very good idea to keep them because they increase the risk of hypoglycemia.

However, I have to say that there are some randomized controlled trials that keep low-dose sulfonylureas with low-dose insulin. But in general, in practice I think it is just a good idea to go off medications that can increase the risk of hypoglycemia, and maybe keep the others that do not increase this risk.

We would love to hear from you

  • Do you have any comments?
  • Have you found a mistake?
  • Would you like to suggest a feature?

We use cookies to ensure you get the best browsing experience on our website. Refer to our Cookies Information and Privacy Policy for more details.