McMaster Textbook of Internal Medicine

NDM-1 resistance: a cause for concern

2018-05-28

Mark Loeb

Why has the emergence of New Delhi Metallo-beta-lactamase-1 (NDM-1) resistance caused concern of disease control authorities?

Mark Loeb: The biggest concern is that this is a very broad beta-lactamase that renders the bacteria resistant to carbapenems. If you cannot treat something with imipenem or meropenem, it makes things a lot more difficult and then we have a very limited array of antibiotics, things like colistin, that have some toxicities potentially, and it may not be that effective. That is really it, the broad range of this beta-lactamase.

See also

How to avoid being misled by the medical literature A lecture by Dr Gordon Guyatt, from McMaster University, Canada, delivered at McMaster International Review Course in Internal Medicine in Kraków in May 2017.
Microbial floras in hospital and community settings What are the key differences between microbial floras in the hospital and community settings?
FMT in C difficile infection What is the role of fecal microbiota transplantation (FMT) in the treatment of Clostridium difficile infection?
Antibiotic resistance: how to handle in clinical practice A lecture by Prof. Mark Loeb, from McMaster University, Canada, delivered at McMaster International Review Course in Internal Medicine in Kraków in May 2016.
Self-administered antibiotics in viral infections What should we do in the case of a patient who has self-administered an antibiotic for a viral infection and approached a physician only after a few days? Is it better to continue or discontinue the drug?
Treating patients with HCV infection Who should treat patients with HCV infection? General practitioners, infectious disease specialists, hepatologists?

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