NDM-1 resistance: a cause for concern

Mark Loeb

Why has the emergence of New Delhi Metallo-beta-lactamase-1 (NDM-1) resistance caused concern of disease control authorities?

Mark Loeb: The biggest concern is that this is a very broad beta-lactamase that renders the bacteria resistant to carbapenems. If you cannot treat something with imipenem or meropenem, it makes things a lot more difficult and then we have a very limited array of antibiotics, things like colistin, that have some toxicities potentially, and it may not be that effective. That is really it, the broad range of this beta-lactamase.

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