Dr Andrew Perrella, Dr Sanjay Sonney, and Dr Duna Basudan, third-year residents from the Department of Medicine at McMaster University, summarize significant changes introduced in Surviving Sepsis Campaign 2021 guidelines, review supporting evidence, and provide residents' perspective on the practical application of guideline-based therapies in sepsis. The webinar was recorded at the Chair's Medical Grand Rounds on November 11, 2021.