Dr Dominik Mertz, associate professor of medicine and director of the Division of Infectious Diseases at McMaster University, and Dr Zain Chagla, associate professor in the Division of Infectious Diseases at McMaster University, look back at how our knowledge and understanding of coronavirus disease 2019 (COVID-19) changed since the pandemic began and provide an update on epidemiology, treatment methods, and available vaccines. The webinar chaired by Dr Mark Crowther was recorded at the Chair’s Medical Grand Rounds on January 4, 2024.